UK Researchers have discovered a new method for treating colitis and other disease related to inflammatory bowel.

The scientists made use of Bacteroides Ovatus, which is contained by people usually in their gut, which they modified genetically for secreting a protein known as KGF-2 when they get exposed to xylan, a sugar. The thing is to raise the existence of KGF-2, which is growth factor that can help in healing the damages caused by bowel diseases that are inflammatory.

Why cannot we give the growth factors of humans directly? Since they are highly unstable when they are distributed orally and the administration systematically needs high dosage which could increase the danger behind unnecessary side effects. The researches have written in the online edition of the journal gut.

Effect of Xylan and Bacteria on Mice

Their research was focused especially on mice containing colitis, which is a category of inflammatory bowel disease. The scientists treated them with the genetically manufacture bacteria to the same mice orally every alternate day, and they braided their drinking water with xylan. For the sake of comparison of results, they did not get the rest of the mice, the bacteria or the xylan drink. When equated with other mice, the ones which got treatment with xylan drink and bacteria had a loss in rectal bleeding, weight loss and inflammation. They also had quicker healing of the tissue damaged with colitis, and also consistent improvement in their stool.

Results by Cardigan

The tests have to be done with human beings and one of the major researches, Mr. Simon Carding, had a discussion about this treatment through mails. He is a mucosal immunology professor at the University of England and he is the integrated biology director. He has stated that the bacteria that were used are usually present in human gut, so patients will have to be treated first for taking these bacteria which they have already and it should be tolerated by them.

The queries which are still not answered as the protocols for dosage, which is planned to be addressed after the studies are complete further. It could be possible for doing a 1 time bacteria dosage regimen which can establish an everlasting colony of such bacteria which are genetically cultivated. Another choice is establishing temporary colony by doing such treatments when flaring up of disease occurs again.

Carding has said that xylan’s natural sources are rice husks, oat kernels and tree barks which are not found in human diet usually. So, patients can complement their diet by taking xylan as a drink. Aninals can tolerate the high density of xylan in drinking water easily and did not exhibit any negative signs for excessive consumption of xylan as per Cardigan’s report.

Cardigan has stated the strategy of employing bacteria could be made use for treating gut diseases which includes the use of delivery agents for interfering with blood vessel formation to feed the tumors in intestine and for delivering the antigens against bacteria, infection and virus prevention.

Taking Statin Pills can reduce blood pressure as per new study. There is another important advantage of taking statins. As per a new study the drugs which help in reducing cholesterol have also been effective for reducing the blood pressure of patients. The research members have stated that it is the very first time that such a study has proven the results of positive effects of statins in human body apart from reducing cholesterol.

The research members evaluated nine hundred and seventy three patients (both men and women) from the region of southern California. The candidates did not have any heart problems or diabetes. The candidates were treated with pravachol, placebo or zocor each day for 6 months continuously.

Blood Pressure and Relation With Statins:

Patients, who took either any of the statin pills, had a small but notable decrease in their blood pressure when they were compared with another group of individuals who were given placebo drugs. The statins were able to reduce both diastolic and systolic blood pressure among the patients and this effect can extend to other patients who suffer from pre-hypertension, people with usual blood pressures and for people who do not take medications for reducing blood pressure. The research and doctor Beatrice Golomb, MD, Phd has stated in the news release about the benefits of taking statins over the blood pressure when compared to people who don’t take such drugs.

Golomb is currently working for California University and he belongs to San Diego medical school. The statins are the best selling drugs which are usually prescribed by doctors for patients with heavy cholesterol in their body. But the physicians have stated that the benefit of health which is got from statin has been more increased as they have some effect on accumulation of plaque in the blood vessels. The blood pressure could be reduced which is because of the reduction of plaque which causes free movement of blood in patients thereby reducing their blood pressure.

Benefits of Low Blood Pressure

The reduction in blood pressure can be associated with decrease in risk for stroke and other diseases related to heart. The authors of the study are suspecting that the use of statins could be helpful in decreasing the risk of stroke and heart related problems among patients who are suffering from such diseases.

The decrease of blood pressure through use of Statins which also help in reducing the cholesterol contents among the patients is like a double edged sword and can be helpful in reducing the problems related to heart like stroke and other cardiovascular diseases that can arise due to high pressure in blood. Golomb has asked his team members to research further with various statin types that can be more powerful and could produce various effects and also with various doses and treatment for longer time frame in order to observe the benefits of this amazing drug further and to provider an effective treatment strategy for reducing blood pressure through statins. The research paper was published in Internal Medicine archive journal.

The lower esophageal sphincter (LES) is situated at the entrance of the stomach. This muscle generally closes as soon food penetrates in it. If LES remains open for a long time then an acid is generated in the stomach that reaches the esophagus and causes a burning sensation called heartburn. If a patient is suffering the ailment and has regular symptoms more than twice a week it is commonly also known as gastroesophageal reflex disease (GERD).

Causes of Acid Reflux Disease

If the stomach has an abnormality called the hiatel hernia this leads to the cause of the ailment. This generally happens when the greater part of the stomach and LES shift above the diaphragm. The diaphragm facilitates the acid out of the stomach but if you have hiatel hernia then the acid would reach the esophagus and cause the ailment.

These are other widespread peril features for acid for the ailment:

• Consuming generous portions of meals
• Being obese
• Consuming a magnanimous meal and resting on your back of the body
• Nasty habit of eating before sleeping
• Consumption of food products like citrus, tomato, chocolate, mint, garlic, onions, or spicy or fatty foods
• Imbibing few drinks like coffee, tea, aerated drinks and alcohol
• Smoking cigarettes
• pregnant women
• Consumption of drugs like asprin, and other blood pressure medicine doses

Symptoms Of Acid Reflux Disease

Heartburn – It causes a burning and acidic sensation that may even travel from the stomach to the chest or even in the throat and cause the discomfort to the patient.

Regurgitation – It is a sour or a bitter tasting acid that comes up in the throat or the mouth.

Additional indications of acid reflux sickness include:

• Gaining weight
• Blood in the stools and vomit
• Regular burping
• Constriction of the esophagus that results in the food being trapped in the throat
• Incessant hiccups
• Nausea
• Weight loss for unknown reasons
• acute sore throat

Diagnosis Of Acid Reflux Disease

If you are suffering for more than two times a week with the symptoms of the Acid Reflux disease you must consult a doctor immediately. Medicines would relief against the burning sensation and there would be a transformation of the lifestyle. Antacids consumption will lower the symptoms of the disease.
If the patient is suffering from acute symptoms and a lot of discomfort is being suffered then the following tests needs to be done.

• Barium swallow (esophagram) test would give an exact idea about the presence of ulcers and the constriction of the esophagus
• Esophageal manometry test can determine the functions of the esophagus and LES in the body
• pH monitoring examination would examine the accumulation of the acid in the esophagus
• Endoscopy medical test would scrutinize all the problems of the esophagus and the stomach.
• A biopsy report will clearly analyze the tissues for any kind of infection and this is done during the endoscopy test.