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Epilepsy Drugs May Treat Alzheimer’s

Posted by Admin | Posted in Alzheimer's, Epilepsy, Health News | Posted on 21-12-2009

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According to recent studies, Alzheimer’s and Parkinson’s disease can be cured by using drugs that are used to cure epilepsy. Researches show neurons in the brain are protected after treatment with T-type calcium-channel blockers, which are commonly used to treat epilepsy.

Scientists have established a link between Alzheimer’s and epilepsy that could lead to more effective treatment of patients with both diseases. Specialists, including academics from Aberdeen University, have discovered that a protein found in the brains of Alzheimer’s sufferers also plays a role in epilepsy. It has been found that to protect brain cells from old age damage and from degeneration, there is no medicine found as off now. Although, if the scientists and the doctors, put a little more effort on it and work on it a little harder, they could come up with more helpful solutions and treatments age-related neurological diseases.

Epilepsy-DrugsCalcium signaling pathways play a vital role in the survival of neurons in the brain. As the age increases, calcium homeostasis can be disrupted in the brain, which may lead to cognitive and functional decline. It therefore raises the possibility that chemicals able to modulate calcium homeostasis could protect neurons in the brain. Researchers found that the brain cells also showed an increase in viability after treatment with the calcium channel blockers over both the long term and short term.

Earlier the mechanism for the protection of these brain cells were not known to the people. With time the scientists explored the possible protective effects of blockers for T-type calcium channels.

They found that neurons showed an increase in viability after treatment with either L-type or T-type calcium channel inhibitors. Furthermore, neurons in the long-term and short-term cultures were protected, respectively, by L-type and T-type calcium channel blockers, suggesting that more than one calcium-signaling mechanism exists to regulate long- and short-term neuron survival.

The study says that this enhances the chances of using chemicals like calcium channel blockers that are are part of the calcium signaling process which guard and take care of the nerve cells in the brain, and protect these nerve cells in the brain from death.

A study has been done on a mice and notices have been made on the brain cells of the mice and how the treatment effects the mice, more so after the treatment with calcium channel blockers.

As the drug is now clinically available and well tolerated, the confirmation of its therapeutic affectivity in humans could be applied to Alzheimers in a shorter period of time than other drugs being studied.Researchers say that their data provides implications for the use of this family of anti-epileptic drugs in developing new treatments for neuronal injury, and for the need of further studies of the use of such drugs in age-related neurodegenerative disorders.

According to a study, BioMed Central’s open access journal Molecular Neurodegeneration, it was found that neurons in the brain were protected after treatment with T-type calcium-channel blockers, which are commonly used to treat epilepsy.

Treat Alzheimer’s By Using Epilepsy Drugs

Posted by Admin | Posted in Alzheimer's, Epilepsy, Health News | Posted on 10-12-2009

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One of the latest discoveries has been that a new group of medicine which is a great remedy for the ailment of epilepsy may also treat the disease of Alzheimer’s and also Parkinson’s ailment. Is this not one of the great news you have heard in a long time?

The latest research clearly portrays that curing the disease by the use of T-type calcium canal blockers was initially used to treat the disease of epilepsy. This method facilitated the protection of the nerve cells that could be easily harmed or damaged by the nerve disorders like Alzheimer’s and Parkinson’s disease.

alzheimers1A group of researchers have concluded that the lack of effective medicine to shield the brain cells from age harming and deteriorating disease has led to the discovery of new drugs and advanced study in this area. These studies if confirmed may lead to ground breaking results in the medical world. A new and revolutionary class of medical doses will surface that would lead to a better and a more effective manner of curing age connected neurological disorders.

Calcium boosting channel play a pivotal role in the growth and existence of neurons in the brain. As human beings age the method becomes complex and this may lead to learning and adequate functioning of the brain may decline with time.

Researchers conclude that this leads to the mushrooming of other avenues and by using calcium blockers the process manifests the growth and protection of neurons. The calcium signaling method is a great way of protecting the neurons.

One of the studies that is published in Molecular Neurodegenaration displays the consequences of the cure with calcium blockers on the cells present in the brain of the mice. One of the conclusions that researchers have zeroed on is that neurons displayed an augment in the cure with the use of calcium channel blockers over long and short term period.

Researcher Jianxin Bao, PhD, of Washington University in St. Louis in a press release stated that the studies have provided adequate data that clearly implies that the use of anti-epileptic doses in growth of recent and latest cures for neurological disorders and injuries.

Discovery Of 3 New Genes Linked With Alzheimer’s Disease By British And French Researches

Posted by Admin | Posted in Alzheimer's, Health News | Posted on 16-11-2009

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French and British Researchers have discovered 3 genes that cause the Alzheimer’s disease that can most probably with several cases of mutations. As per the online report given by the scientists in Nature Genetics, the finding of these 3 important genes named as CR1, PICALM and CLU can be a good treatment for the Alzheimer’s disease.

These genes were discovered by making a comparison of 1000s of DNA samples from Americans and Europeans, both who were infected with the Alzheimer’s disease and people without it. There are certain other genes which are also related with the cause of Alzheimer’s disease especially the APOE4 gene version is found to be major risk factor that can cause Alzheimer’s disease, and further many gene discoveries can happen soon, as stated by the researchers.

For example, during the month of June 2008, another crew of researchers stated that a gene named TOMM40 can be a strong forecaster of the Alzheimer disease. Julie Williams, PhD, is a lecturer and export in neuropsychological genetics who works at Cardiff University in United Kingdom. She was one of the scientists in the crew which discovered the 3 new genes related to the Alzheimer’s disease.

The genes CLU, CR1 and APOE have major role in safe guarding the brain from impairment. Probably, the alternation seen in these genes can damage their protective behavior and can even change them to killer genes. Around sixteen thousand individuals were studied for this research in order to discover these new gene variants. These genes are the first news ones to be linked with generic form of Alzheimer’s disease since its discovery in 1993.

alzhimers-2The trust for Alzheimer’s Research stated that is a leap ahead for research in dementia. Michal Owen, the member of Medical Research Council stated that this discovery is a big milestone towards achieving an early cure of the Alzheimer’s disease. Julie Williams one of the lead authors of this research paper, states on the website named Nature Genetics where it was published that these newly invented genes would become a portion of the a wide genetic exam to find out the risk of Alzheimer’s disease, but they will not individually contribute a complete gene test on their own. Owen who is director at MRC center in Cardiff University handling for Neuropsychiatric Genetics and Genomics has also stated the same.

Earlier only 1 type of gene, APOE4, was liked with the Alzheimer’s disease. This analysis has disclosed 2 more genes, PICALM and CIU to be linked with the Alzheimer’s disease. This is anticipated to present researches much more percipient direction for developing new method of treatments for the disease. The crew of researchers also shared their research data with another study by French researchers, which finally exposed the obliging manifest for a 3rd gene linked with Alzheimer’s disease termed as CR1.

The lead author of the research paper and principal scientific advisor for the Alzheimer’s research trust and professor at Cardiff University, Julie Williams, has reported that this research has changed the understanding of the scientists about the common causes behind the Alzheimer’s disease and has given them leads for finding new optimal treatment techniques and possible cures for this dementia. The research paper was published in the Nature Genetics website. Owen has also stated that a bigger study and research is planned to discover more Alzheimer’s gene targets.